Journal: Kidney International Reports
Article Title: Endothelial Dysfunction Biomarkers and CKD Incidence in the REGARDS Cohort
doi: 10.1016/j.ekir.2024.04.056
Figure Lengend Snippet: Odds ratios and 95% CIs for incident CKD per 1 SD increment of biomarkers of endothelial dysfunction. a Model 1 was unadjusted. b Model 2 adjusted for age, sex, race, and geographic region of residence. c Model 3 was further adjusted for body mass index, hypertension, diabetes, coronary artery disease, smoking status, and dyslipidemia. d Model 4 was further adjusted for baseline eGFR and ACR. 1 log-transformed SD was, as follows: ICAM-1, 0.25 ln(ng/ml); VCAM-1, 0.36 ln(ng/ml); factor VIII, 0.32 ln (%); E-selectin, 0.46 ln(ng/ml). Regression models were weighted to reflect the entire cohort from which this subcohort was sampled. ACR, urinary albumin-to-creatinine ratio; CI, confidence interval; CKD, chronic kidney disease defined by eGFR <60 ml/min per 1.73 m 2 plus 40% decline from baseline or new kidney failure; eGFR, estimated glomerular filtration rate by 2021 CKD-EPI equation by serum creatinine and cystatin C; ICAM-1, intercellular cellular adhesion molecule 1.
Article Snippet: Each biomarker was measured using commercially available enzyme-linked immunoassays: FVIII antigen by Affinity Biologicals (F8C-Elisa; Hamilton, Ontario, Canada) and the remainder by R&D Systems (ICAM-1 by CDIM00, VCAM-1 by DVC00, and E-selectin by PDSLE00; Minneapolis, MN).
Techniques: Transformation Assay, Filtration